SUNDAY, JULY 6, 2008

1:00 pm – 6:00 pm

Registration

6:00 pm – 8:00 pm

Welcome Reception (Saratoga Hilton Foyer)

MONDAY, JULY 7, 2008

8:30 am – 10:00 am

PLENARY SESSION 1       Saratoga 1 & 2

PL 1 Structure/Function Relationships of Drug Metabolizing Enzymes: Predictions of Drug Metabolism (Eric Johnson and James Halpert – Chairs)

Structure and Function of P450 2B and 3A Enzymes: Role of Conformational Flexibility and Heterogeneity (James Halpert)

X-Ray Crystallography as a Tool for Understanding P450 2C Structure/Function Relationships (Eric Johnson)

Structure/Function Relationships of Human UDP-Glucuronosyltransferases (John Miners)

10:05-10:25 am

Coffee Break

10:30 am – 12:00 pm

PLENARY SESSION 2 Saratoga 1 & 2

Tribute to Werner Kalow (Denis Grant and Rachel Tyndale)

PL 2 Pharmacogenomics in Drug Treatment
(Magnus Ingelman-Sundberg and Steven Leeder – Chairs)

Pharmacogenomics in Drug Treatment (Magnus Ingelman-Sundberg)

Pharmacogenomics of Adverse Drug Reactions (Munir Pirmohamed)

TBA (Todd Skaar)

12:00 pm – 1:30 pm  

 Celsis In Vitro Technologies Lunch Presentation Saratoga 1 & 2  Defined Activities of Human Liver Microsomes Based on Application
 

12:00 pm – 2:40 pm

Poster Viewing (Abstracts 1-40)

2:45 pm – 4:15 pm

SYMPOSIUM 1 Saratoga 1 & 2

SY 1 Engineered P450s as Novel Biocatalysts (Nico Vermeulen and Rita Bernhardt – Chairs)

Engineered Bacterial P450 BM3: Novel Tools in Drug Discovery and Drug Metabolism Studies (Nico Vermeulen)

Engineered Steroid Hydroxylating P450s for Changed Substrate Specificity and Biosynthesis of Steroid Hormones (Rita Bernhardt)

Bioengineering flavocytochrome P450 BM3 for novel substrate specificity and enhanced stability (Hazel Girvan)

2:45 pm – 4:15 pm

SYMPOSIUM 3 Saratoga 3

SY 3 Prediction of Drug Interactions from In Vitro Data (Aleksandra Galetin and Scott Obach – Chairs)

Impact of intestinal CYP3A on Prediction of Drug-Drug Interactions (Aleksandra Galetin)

Prediction of DDI for Mechanism Based Inactivators: Balancing the Accuracy of System Information vs. the Adequate Characterisation of Compounds (Amin Rostami-Hodjegan)

Prediction of DDI for liver transporters (Richard Kim)

4:20 pm – 4:40 pm

Coffee Break

4:45 pm – 6:15 pm

SYMPOSIUM 2 Saratoga 1 & 2

SY 2 P450s as Drug Targets (Mike Waterman and Kan Chiba – Chairs)

CYP51 as a Potential Target for Treatment of Human Infections with Trypanosomatidae
(Galina Lepesheva)

The arachidonate Monoxygenase: A New Target for Drug Design and Evaluation
(Jorge Capdevila)

Biochemical and Biophysical Studies of Cholesterol-Metabolizing Cytochrome P450 46A1: Some Unanticipated Findings (Irina Pikuleva)

4:45 pm – 6:15 pm

SYMPOSIUM 4 Saratoga 3

SY 4 Pharmacokinetic Modeling and Drug Development (Geoff Tucker and Carl Peck – Chairs)

Prediction of Pharmacokinetics and its Variability (Geoff Tucker)

Why and How Regulatory Agencies have Integrated Advances in Drug Metabolism into New Drug Requirements (Carl Peck)

Modeling and Simulation in Modern Drug Development (Don Stanski)

6:30 pm

Depart for Polo Match/Dinner

TUESDAY, JULY 8, 2008

8:30 am – 10:00 am

PLENARY SESSION 3 Saratoga 1 & 2

PL 3 Biotechnology in Drug Discovery and Development
(Yoshihide Hayashizaki and Linda Griffith – Chairs)

Ultrafast Molecular Diagnosis for Clinical Practice (Yoshihide Hayashizaki)

Microscale Models of Liver (Linda Griffith)

Microdevices for Biomolecular Detection and Single Cell Analysis (Scott Manalis

10:05 am – 10:25 am

Coffee Break

10:30 am – 12:00 pm

PLENARY SESSION 4 Saratoga 1 & 2

PL 4 Systems Biology in Drug Metabolism and Development
(Ulrich Zanger and Roland Wolf – Chairs)

A Systems Biology Approach for Quantitative Analysis of Dynamic Cellular Processes During Drug Detoxification in Human Hepatocytes
(Matthias Reuss)

Computational Systems Biology Approaches for Drug Metabolism and Beyond (Sean Ekins)


CAR/PXR Regulatory Networks: Relationship to Drug Metabolism and Fatty Acid Homeostasis (Roland Wolf)

12:00 pm – 1:30 pm

BD Biosciences Lunch and Product Presentation Saratoga 1 & 2

12:00 pm – 2:40 pm

Poster Viewing (Abstracts 41-80)

2:45 pm – 4:15 pm

SYMPOSIUM 5 Saratoga 1 & 2

SY 5 P450/P450 Reductase Prodrug Activation in Cancer Therapy
(David Waxman and Yan Li – Chairs)

Liver-Targeted Drug Delivery Using Hep-Direct (tm) Prodrugs (Mark Erion)

Cancer Therapy Using Cytochrome P450 Genes (David Waxman)

Activation and Detoxication of Ellipticine, a Model Anticancer Prodrug: Enzymes, DNA Adducts, Effects (Marie Stiborova)

2:45 pm – 4:15 pm

SYMPOSIUM 7 Saratoga 3

SY 7 Nanotechnology Applications to Mechanism and Therapies
(William Atkins and Steven Sligar - Chairs)

Nanotechnology, Drug Metabolism and Enzyme Cooperativity (Steven Sligar)

"Smart" Polymeric Carriers for Biomolecules That Talk and Listen in Nanospace
(Patrick Stayton)

Single Molecule Spectroscopy Studies of CYP3A4 in Lipid Nanodiscs
(Elizabeth Rhoades)

4:20 pm – 4:40 pm

Coffee Break

4:45 pm – 6:15 pm

SYMPOSIUM 6 Saratoga 1 & 2

SY 6 Postgenomic High-Throughput Techniques for Analysis of Drug Metabolizing Systems (Dennis Smith and Jonathan Dordick – Chairs)

Progress and Gaps in Screening Systems Over the Last Decade (Dennis Smith)

CCR Antagonists for HIV Therapy; The Discovery of Maraviroc (David Price)

Human Metabolism and Toxicology at Lightening Speed (Jonathan Dordick)

4:45 pm – 6:15 pm

SYMPOSIUM 8 Saratoga 3

SY 8 Stem Cell-Based New Cellular Systems for Drug Metabolism and Toxicity Testing
(Craig Marcus and Patrick Maurel – Chairs)

General Introduction on Human Liver Stem Cells (Malcolm Alison)

Generation of Hepatocytes from Human Adult Stem Cells (Robert Schwartz)

Generation of Hepatocyte-like Cells from Human Adult and Embryonic Stem Cells (Patrick Maurel)

7:30 pm

Banquet Saratoga Hilton Ballroom

WEDNESDAY, July 9, 2008

8:30 am – 10:00 am

PLENARY SESSION 5 Saratoga 1 & 2

PL 5 Regulation of and by Xenobiotic Nuclear Receptors
(Urs Meyer and Masahiko Negishi – Chairs)

The Activation Mechanisms of the Nuclear Receptors CAR and PXR (Masahiko Negishi)

Nuclear Receptor-Mediated Regulation of Phase II Sulfotransferases (Wen Xie)

Identification of a novel PXR target gene linking PXR activation to hepatic de novo lipogenesis in human hepatocyte (Jean-Marc Pascussi)

10:05 am – 10:25 am

Coffee Break

10:30 am – 12:00 pm

PLENARY SESSION 6 Saratoga 1 & 2

PL 6 Micro RNA and Epigenetic Control of Drug Metabolism
(Allan Okey and Tsuyoshi Yokoi – Chairs)

MicroRNAs Regulate the Expression of Human Cytochrome P450 1B1 and P450 3A4
(Tsuyoshi Yokoi)

Dioxin Affects MicroRNA Expression Differently in Mouse Fetal Tissues than in Adult
(Patricia Harper)

Epigenetic Regulation of CYP1A1 Expression (Alvaro Puga)

12:30 pm

Fort William Henry/Dinner Cruise, Lake George, NY

THURSDAY, July 10, 2008

8:30 am – 10:00 am

PLENARY SESSION 7 Saratoga 1 & 2

PL 7 Mouse Xenobiotic Metabolism Models: Transgenics, Knockouts, and Humanized Mice (Xinxin Ding and Frank Gonzalez – Chairs)

P450 and Xenobiotic Receptor Humanized Mice (Frank Gonzalez)

Insights From Transgenic And Humanized UDP-glucuronosyltransferase 1 Mice
(Robert Tukey)

Xenobiotic Metabolism Models Targeting the P450 Reductase (Xinxin Ding)

10:05 am – 10:25 am

Coffee Break

10:30 am – 12:00 pm

PLENARY SESSION 8 Saratoga 1 & 2

PL 8 Transporters and Transporter-P450 Interplay
(Heyo Kroemer and Les Benet – Chairs)

Transporter-Enzyme Interplay in Predicting Drug Absorption and Disposition (Les Benet)

CYPs and Transport Proteins in the Cardiovascular System
(Heyo Kroemer)

Which determines the drug exposures in the plasma and liver? Uptake/efflux transporters or enzymes? (Hiroyuki Kusuhara)

12:00 pm – 1:30 pm

Promega Lunch and Product Presentation Saratoga 1 & 2

12:00 pm – 2:40 pm

Poster Viewing (Abstracts 81-123)

2:45 pm – 4:15 pm

SYMPOSIUM 9 Saratoga 1 & 2

SY 9 Drug Conjugation: Recent Developments and their Clinical Impact
(Peter MacKenzie and David Rodrigues – Chairs)

Interspecies Differences in Sulfation Catalysed by Cytosolic Sulfotransferases: Implications for Drug Development and Chemical Safety Assessment (Mike Coughtrie)

Arylamine N-acetyltransferases: Structure, Functions, Animal Models and Toxicological Consequences (Denis Grant)

Factors that control UDP Glucuronosyltransferase gene expression (Peter Mackenzie)

2:45 pm – 4:15 pm

SYMPOSIUM 11 Saratoga 3

SY 11 Reactive Drug Metabolites: New Developments
(Thomas Baillie and F. Peter Guengerich – Chairs)

Toxicogenomics, Oxidative Stress and Idiosyncratic Hepatotoxicity (Michael McMillian)

The Chemistry of Metabolic Activation – Reactive Intermediates from Heterocycles
(Thomas Baillie)

Direct Mapping of Sites of Modification of DNA Fragments Using Tandem Mass Spectrometery Detection and Mapping of Sites of Base Modification in DNA (Fred Guengerich)

4:20 pm – 4:40 pm

Coffee Break

4:45 pm – 6:15 pm

SYMPOSIUM 10 Saratoga 1 & 2

SY 10 Extrahepatic Drug Metabolism
(Anthony Lu and Rachel Tyndale – Chairs)

Enzymes of the CYP2 Family are Uniquely Expressed and Regulated in the Brain
(Rachel Tyndale)

Expression of CYPs in Extrahepatic Tissues (Isabelle de Waziers)

Selectively Expressed Cytochrome P450 Enzymes Control Pneumotoxicities and Lung Cancer (Garold Yost)

4:45 pm – 6:15 pm

SYMPOSIUM 12 Saratoga 3

SY 12 Early ADME and Improved Candidate Drugs
(Dennis Smith and David Spink – Chairs)

Early ADME: Brickdust, Dreams and Reality (Dennis Smith)

Integration of Early ADME and In Silico Data for Improved Candidate Drug Selection
(Stefan Steyn)

Improving DMPK Properties in the Discovery of 5-HT1B Antagonists for Depression
(Minli Zhang)

6:15 pm – 6:30 pm

Presentation of Future Meetings Saratoga 1 & 2

6:30 pm

Closing of Symposium Saratoga 1 & 2